Center for Clinical Investigation

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Statistical Sciences Core

About Us

Members of the CCI’s Statistical Sciences Core are partially supported by the CTSC Biostatistics, Epidemiology, and Research Design Core and provide clinical data management and statistical support to CWRU and University Hospitals Case Medical Center investigators.

With respect to clinical data management support, Core members include skilled clinical data managers/programmers who collaborate with investigators on:

    • Proposal development, especially for grant applications
      • Writing data management plans
      • Developing an appropriate budget for clinical data management
    • Case report form development and coding
    • RedCap database development and administration
    • Data cleaning and quality assurance
    • Scoring of validated questionnaires
    • Statistical programming and dataset preparation
    • Education and training on clinical data management

With respect to statistical support, Core members include PhD and Masters level statisticians who collaborate with investigators on:

    • Proposal development, especially for grant applications
      • Critiquing and improving study designs
      • Producing custom, detailed statistical considerations sections
      • Study monitoring
      • Assessing data quality for ongoing studies
      • Evaluating proposed changes to studies in progress
      • Formal interim analyses for clinical trials
      • Developing an appropriate budget for statistical support
    • Modern and appropriate data analyses
      • Summarizing data using graphics and tables
      • Forming custom statistical approaches to test specific research hypotheses
      • Learning from rich datasets, that is, discovering patterns and relationships that suggest new research questions for subsequent studies
      • Interpreting statistical results prudently
      • Reporting analyses for presentations and publications

Members

Interim Director

Ralph O'Brien, PhD

Biostatisticians

Hong Li, MS

Penny Benchek, MS

Jarrod Harding, MS

Clinical Data Managers

Tom Rehman, MA, MPH

Office Hours

Basic science and clinical investigators in the CWRU School of Medicine or University Hospitals Case Medical Center are welcome to meet with CCI biostatisticians and clinical data managers in our research offices in Wolstein Research Building, Suite 6136.

Appointments are required, and must be scheduled 72 hours in advance. Please use the links below to schedule a meeting with one of our team members.


CLICK HERE TO SCHEDULE WITH A BIOSTATISTICIAN

CLICK HERE TO SCHEDULE WITH A CLINICAL DATA MANAGER


If you cannot find a time on our calendar, please contact Ralph O'Brien, Interim Director of the CCI Statistical Sciences Core, at obrienralph@gmail.com, to schedule another time.

Questions regarding study design, clinical data management, statistical software, and data analysis and interpretation are encouraged and will be addressed on a first come, first serve basis. Please note that each investigator receives one free hour of statistical support and so additional support will be charged at an hourly rate.

Collaborate With Us

Investigators are welcome to contact Ralph O'Brien, Interim Director of the CCI Statistical Sciences Core, at obrienralph@gmail.com, to discuss how they can begin collaborating with the Core. More detailed information can also be found on the CCI Collaboration page.